Grade 5.p65
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Role of nuclear factor-κB in female breast cancer: a study in Indian patients.
INTRODUCTION The nuclear factor κB (NF-κB) is a super family of transcription factors which plays important roles in development and progression of cancer. The present investigation concerns NF-κB /p65 activity in human breast cancers with overexpression of ER, PR, HER-2/neu, as well as the significance of p65 expression with regard to menopausal status, stage, grade, tumor size, nodal status, ...
متن کاملConstitutive activation of nuclear factor -kB: preferntial homodimerization of p50 subunits in cervical carcinoma.
Infection of specific types of 'high risk' HPVs such as HPV 16 and HPV 18 has been associated with the development of cervical cancer. Deregulation of specific NF-kappaB members has also been implicated with the development of many cancers including cervical cancer. We have studied the expression and DNA-binding activity of NF-kappaB during the development of cervical cancer involving cervical ...
متن کاملاثر مهاری کورکومین بر فسفریلاسیون NFκB-p65 القاشده توسط هیدروژن پراکسید در سلول‌های اندوتلیال آئورت گاوی
زمینه و هدف: NFκB یک فاکتور هسته‌ای دایمر و دارای چندین زیرواحد است. p65 یکی از زیرواحدهای NFκB است که فسفریلاسیون آن در اثر استرس اکسیداتیو به فعال شدن NFκB منجر می‌گردد. عدم تعادل میان استرس اکسیداتیو و ظرفیت آنتی‌اکسیدانی در پاتوژنز بسیاری بیماری‌ها مشارکت می‌کند. استفاده از ترکیبات آنتی‌اکسیدانی می‌تواند به‌عنوان استراتژی پیشگیری بیماری‌های التهابی موردتوجه قرار گیرد. از میان ترکیبات آنتی‌ا...
متن کاملERbeta regulation of NF-kB activation in prostate cancer is mediated by HIF-1
We examined the regulation of NF-κB in prostate cancer by estrogen receptor β (ERβ) based on the inverse correlation between p65 and ERβ expression that exists in prostate carcinomas and reports that ERβ can inhibit NF-κB activation, although the mechanism is not known. We demonstrate that ERβ functions as a gate-keeper for NF-κB p65 signaling by repressing its expression and nuclear translocat...
متن کاملERβ regulation of NF-κB activation in prostate cancer is mediated by HIF-1
We examined the regulation of NF-κB in prostate cancer by estrogen receptor β (ERβ) based on the inverse correlation between p65 and ERβ expression that exists in prostate carcinomas and reports that ERβ can inhibit NF-κB activation, although the mechanism is not known. We demonstrate that ERβ functions as a gate-keeper for NF-κB p65 signaling by repressing its expression and nuclear translocat...
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